What question did this study set out to answer?

Summarize dendritic cell biology, classification, and heterogeneity while evaluating their therapeutic and monitoring applications in cancer immunotherapy.

January 21, 2019Frontiers in ImmunologyOpen Access

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

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Authors

TPThiago A. PatenteLeiden University Medical Center MPMariana Pereira PinhoChinese Academy of Medical Sciences & Peking Union Medical College AOAline A. OliveiraUniversidade Federal de Lavras

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Implication

Review highlights dendritic cell heterogeneity and therapeutic roles in cancer patients, suggesting new opportunities for combination immunotherapy.

Key Points

Summarize dendritic cell biology, classification, and heterogeneity while evaluating their therapeutic and monitoring applications in cancer immunotherapy.
Narrative review synthesizing current literature on human dendritic cell physiology, classification, and functional plasticity.
Evaluation of clinical strategies incorporating dendritic cells as therapeutic vaccines, immune monitoring biomarkers, and partners in combination cancer regimens.
Dendritic cells function as specialized antigen-presenting cells that direct both active immunity via naïve T cell activation and immune tolerance under steady-state conditions.
High phenotypic and functional plasticity across dendritic cell subsets allows microenvironment-dependent tuning of immune responses but complicates standard classification schemes.
Clinical utilization of dendritic cells demonstrates strong potential in targeted cancer management and emerging combination immunotherapies.

Cite This Study

Patente et al. (2019) studied this question.

synapsesocial.com/papers/6a6e12e335aa2c282ce01ec9 https://doi.org/10.3389/fimmu.2018.03176

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Implication

Review highlights dendritic cell heterogeneity and therapeutic roles in cancer patients, suggesting new opportunities for combination immunotherapy.

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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