Key result
In healthy volunteers, atenolol 100 mg had the greatest beta2-blocking effect on terbutaline-induced responses, whereas nebivolol 5 mg had the least, indicating it is the most beta1-selective.
Why the study?
Do different beta1-selective beta-blockers (nebivolol, bisoprolol, atenolol) differ in their beta1-selectivity as measured by beta2-mediated responses to terbutaline in healthy volunteers?
Population
24 healthy volunteers (14 men, 10 women) with no history of respiratory disease
Comparison
Nebivolol 5 mg, bisoprolol 10 mg, atenolol 50… vs Placebo administered orally
Design
RCT, supplied in random order
Follow-up
up to 30-min post-infusion
Authors
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Supports nebivolol selection to limit beta2 effects in at-risk patients; confirms its superior beta1-selectivity versus atenolol in RCT.
RCT (n=24)
Random order
Do different beta1-selective beta-blockers (nebivolol, bisoprolol, atenolol) differ in their beta1-selectivity as measured by beta2-mediated responses to terbutaline in healthy volunteers?
Nebivolol 5 mg demonstrates greater beta1-selectivity than bisoprolol 10 mg and atenolol 50/100 mg in healthy volunteers.
Nuttall et al. (2003) conducted an RCT in Healthy volunteers (n=24). Nebivolol, bisoprolol, and atenolol vs. Placebo was evaluated on Beta2-mediated haemodynamic and biochemical responses to a terbutaline infusion. In healthy volunteers, atenolol 100 mg had the greatest beta2-blocking effect on terbutaline-induced responses, whereas nebivolol 5 mg had the least, indicating it is the most beta1-selective.
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