Key result
Atherosclerotic plaques harbor ~23-fold higher apoptotic microparticles compared to underlying arterial walls.
Why the study?
The specific role of apoptosis in human atherosclerosis and its contribution to plaque thrombogenicity remains unknown.
Population
16 human atherosclerotic plaques and 6 plaque extracts with 3 underlying arterial walls
Comparison
Atherosclerotic plaques versus underlying arterial walls
Design
Observational immunohistochemical and biochemical analysis
Authors
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Apoptotic microparticles may enhance plaque thrombogenicity; hypothesis-generating for their role as therapeutic targets in atherosclerosis.
Observational (n=16)
Absolute Event Rate: 29.5% vs 1.3%
p-value: p=<0.02
Mallat et al. (1999) conducted an observational in Atherosclerosis (n=16). Atherosclerotic plaques vs. Underlying arterial walls was evaluated on Shed membrane apoptotic microparticles (phosphatidylserine equivalent in nmol/L) (p=<0.02). Atherosclerotic plaques contained significantly higher levels of shed membrane apoptotic microparticles compared to underlying arterial walls (29.5 vs 1.3 nmol/L, P<0.02).
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