Key result
Normothermic machine perfusion enables viability assessment and reconditioning of previously discarded liver grafts, though the boundaries of this technology remain unclear.
Normothermic machine perfusion enables the viability assessment and reconditioning of previously discarded liver grafts, though the boundaries of its efficacy remain to be fully defined.
The introduction of normothermic machine perfusion (NMP) has revolutionized the landscape of liver transplantation. By enabling the viability assessment and reconditioning of organs, NMP has allowed for the use of previously discarded grafts from extended criteria donors, including those from donation after circulatory death (DCD) donors or macrosteatotic grafts, by mitigating ischemic reperfusion injury (IRI), a significant challenge in the early postoperative period. While the efficacy of NMP in transforming “unusable” organs viable has been demonstrated, the boundaries of this technology remain unclear.
No takes yet. Share an insight, caveat, or question.
Nakayama et al. (2024) conducted a review in Liver transplantation. Normothermic machine perfusion (NMP) was evaluated. Normothermic machine perfusion enables viability assessment and reconditioning of previously discarded liver grafts, though the boundaries of this technology remain unclear.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: