Key result
β-adrenoreceptors do not inhibit sympathetic vasoconstriction in resting or contracting muscle of male or female rats, regardless of training status.
β-adrenoreceptors do not contribute to the regulation of sympathetic vasoconstriction in skeletal muscle or underlie sex differences in neural control of circulation in rats.
Does not implicate β-adrenoreceptors in muscle sympatholysis; leaves open alternative mechanisms for human studies.
β-adrenoreceptors do not inhibit sympathetic vasoconstriction in resting or contracting muscle of male or female rats, regardless of training status. Sympatholysis was enhanced in female, compared to male rats; however, β-adrenoreceptors were not responsible for the enhanced sympatholysis. These findings indicate that β-adrenoreceptors do not contribute to the regulation of sympathetic vasoconstriction in resting and contracting skeletal muscle and suggest that β-adrenoreceptors do not underlie sex differences in the neural control of the circulation.
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Cooper et al. (2020) studied this question. Exercise training and sex was evaluated on Sympathetic vasoconstriction in resting and contracting muscle. β-adrenoreceptors do not inhibit sympathetic vasoconstriction in resting or contracting muscle of male or female rats, regardless of training status.
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