Key result
An abnormal D-dimer at the time of oral anticoagulant withdrawal was associated with an 8.3% rate of recurrent VTE, compared to 0% in patients with a normal D-dimer.
Why the study?
Does an abnormal D-dimer at and 1 month after anticoagulant withdrawal predict recurrent VTE in patients with a first idiopathic proximal DVT?
Cohort (n=64)
No
Does an abnormal D-dimer at and 1 month after anticoagulant withdrawal predict recurrent VTE in patients with a first idiopathic proximal DVT?
Answers are grounded in this paper and cite their sources.
An abnormal D-dimer at the time of withdrawal and 1 month after vitamin K antagonist discontinuation is an independent risk factor for recurrent VTE after a single episode of idiopathic proximal DVT.
Under-anticoagulation with a Vitamin K antagonist (VKA), increases the risk of thrombotic events, and over-anticoagulation increases the risk of serious bleeding. The narrow therapeutic range of VKAs is further complicated by numerous drug, diet, and metabolic interactions
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Tamizifar et al. (2014) conducted a cohort in First episode of idiopathic proximal deep vein thrombosis (n=64). Abnormal D-dimer vs. Normal D-dimer was evaluated on Recurrent venous thromboembolism. An abnormal D-dimer at the time of oral anticoagulant withdrawal was associated with an 8.3% rate of recurrent VTE, compared to 0% in patients with a normal D-dimer.
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