Key result
Early administration of surgical antimicrobial prophylaxis within 30 minutes before incision significantly reduced the adjusted risk of surgical site infection compared to administration 30 to 60 minutes before incision (OR 0.7).
Why the study?
The study was conducted to obtain precise information on the optimal time window for surgical antimicrobial prophylaxis administration before surgical incision.
Does administering surgical antimicrobial prophylaxis 30 to 0 minutes before incision reduce surgical site infection in patients undergoing elective inguinal hernia repair compared to 60 to 30 minutes before incision?
Observational (n=500)
No
Does administering surgical antimicrobial prophylaxis 30 to 0 minutes before incision reduce surgical site infection in patients undergoing elective inguinal hernia repair compared to 60 to 30 minutes before incision?
Odds Ratio: 0.7 (95% CI 0.32–1.21)
Absolute Event Rate: 9.5% vs 8.8%
p-value: p=0.02
Administering surgical antimicrobial prophylaxis within 30 minutes prior to incision significantly reduces the risk of surgical site infection in elective inguinal hernia repair compared to administration 30-60 minutes prior.
Early SAP (0–30 min pre-incision) was associated with lower SSI risk in hernia repair; leaves open optimal timing confirmation in prospective trials.
Background: Preoperative antibiotic prophylaxis is administering antibiotics before performing surgery to help decrease the risk of postoperative infections. The antibiotic selected should only cover the likely pathogens. It should be given at the correct time. The timing of antibiotic administration may vary, but the goal of administering preoperative systemic prophylactic antibiotics is to have the concentration in the tissues at its highest at the start and during surgery. The literature supports at least 30 minutes, but no greater than 60 minutes before the skin incision is made to the optimal timing for the preoperative administration of most commonly used antibiotics. Aims and Objectives: To obtain precise information on the optimal time window for surgical antimicrobial prophylaxis (SAP). Methodology: A retrospective observational study design was used to investigate the effect of timing of SAP on the risk of surgical site infection (SSI) from September 2021 until September 2022. Patients with Inguinal hernia who performed elective inguinal hernia repair were eligible for enrollment in the study. The risk of SSI was compared between patients, categorized by the time interval between SAB administration and incision, and adjusted for confounding through Univariate Analysis logistic regression. Hakeem data base was used to collect the required data. This study was performed in King Hussein Medical Center (KHMC) at the Royal Medical Services in Amman/Jordan. Results: Data included in the current study was collected for the period between September 2021 until September 2022, in which 500 patients were randomly assigned into two arms; Patients in arm A received the in a time window of 60 to 30 minutes before the scheduled incision while Patients in arm B received the antibiotics in time window of less than 30 minutes to 0 minutes before the scheduled incision. In 52% of the procedures, SAP was administered within 60 minutes before incision Inpatient and ...........
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Odah et al. (2023) conducted an observational in Elective inguinal hernia (n=500). Surgical antimicrobial prophylaxis 0-30 minutes before incision vs. Surgical antimicrobial prophylaxis 30-60 minutes before incision was evaluated on Surgical site infection within 30 days after surgery (OR 0.7, 95% CI 0.32-1.21, p=0.02). Early administration of surgical antimicrobial prophylaxis within 30 minutes before incision significantly reduced the adjusted risk of surgical site infection compared to administration 30 to 60 minutes before incision (OR 0.7).
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