Mechanistic review uncovers oncogenic gain of function by mutant p53 in diverse malignancies, highlighting promising therapeutic targets for cancer treatment.
Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.
No takes yet. Share an insight, caveat, or question.
Müller et al. (2014) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: