Key result
The LL homozygote of 5-HTTLPR and 10/10 homozygote of 5-HTTVNTR were associated with a significantly increased risk of VSD-related ultrasonographic pulmonary arterial hypertension.
Why the study?
Are serotonin transporter (5-HTT) gene polymorphisms associated with an increased risk of VSD-related ultrasonographic pulmonary arterial hypertension in a Chinese population?
Case-Control
Are serotonin transporter (5-HTT) gene polymorphisms associated with an increased risk of VSD-related ultrasonographic pulmonary arterial hypertension in a Chinese population?
Answers are grounded in this paper and cite their sources.
Polymorphisms in the serotonin transporter gene (5-HTTLPR and 5-HTTVNTR) may increase susceptibility to pulmonary arterial hypertension in Chinese patients with ventricular septal defects.
Polymorphisms of serotonin transporter (5-HTT) gene were hypothesized to be associated with ventricular septal defects (VSD) related ultrasonographic pulmonary arterial hypertension (PAH) susceptibility. To test this hypothesis, we performed a case-case study in Chinese population and genotyped two polymorphisms (5-HTTLPR and 5-HTTVNTR). The LL homozygote of 5-HTTLPR and 10/10 homozygote of 5-HTTVNTR were both associated with a significantly increased risk of VSD-related ultrasonographic PAH. Haplotype analysis showed haplotype L-10 were also associated with a significant increased risk of ultrasonic PAH. These findings suggest that 5-HTT polymorphisms may play a role in the etiology of VSD-related possible PAH.
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Cao et al. (2009) conducted a case-control in Ventricular septal defects (VSD) related ultrasonographic pulmonary arterial hypertension (PAH). Serotonin transporter (5-HTT) gene polymorphisms (5-HTTLPR and 5-HTTVNTR) was evaluated on VSD-related ultrasonographic PAH susceptibility. The LL homozygote of 5-HTTLPR and 10/10 homozygote of 5-HTTVNTR were associated with a significantly increased risk of VSD-related ultrasonographic pulmonary arterial hypertension.
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