Key result
Being overweight or obese was not related to the occurrence of late adverse outcomes, including myocardial infarction, stroke, death, or restenosis, after a carotid endarterectomy.
Why the study?
The association of an increased body mass index with late adverse outcomes after carotid endarterectomy was not well established.
Does increased body mass index prevent late major adverse outcomes in patients undergoing carotid endarterectomy?
Cohort (n=1,533)
No
Does increased body mass index prevent late major adverse outcomes in patients undergoing carotid endarterectomy?
Overweight and obesity status defined by BMI do not predict late cardiovascular events, mortality, or restenosis four years after carotid endarterectomy.
Answers are grounded in this paper and cite their sources.
BMI does not predict late events after carotid endarterectomy; leaves open whether weight affects post-procedural risk.
A cohort study was conducted to examine the association of an increased body mass index (BMI) with late adverse outcomes after a carotid endarterectomy (CEA). It comprised 1597 CEAs, performed in 1533 patients at the Vascular Surgery Clinic in Belgrade, from 1 January 2012 to 31 December 2017. The follow-up lasted four years after CEA. Data for late myocardial infarction and stroke were available for 1223 CEAs, data for death for 1305 CEAs, and data for restenosis for 1162 CEAs. Logistic and Cox regressions were used in the analysis. The CEAs in patients who were overweight and obese were separately compared with the CEAs in patients with a normal weight. Out of 1223 CEAs, 413 (33.8%) were performed in patients with a normal weight, 583 (47.7%) in patients who were overweight, and 220 (18.0%) in patients who were obese. According to the logistic regression analysis, the compared groups did not significantly differ in the frequency of myocardial infarction, stroke, and death, as late major adverse outcomes (MAOs), or in the frequency of restenosis. According to the Cox and logistic regression analyses, BMI was neither a predictor for late MAOs, analyzed separately or all together, nor for restenosis. In conclusion, being overweight and being obese were not related to the occurrence of late adverse outcomes after a carotid endarterectomy.
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Vukašinović et al. (2023) conducted a cohort in Carotid artery stenosis requiring endarterectomy (n=1,533). Increased body mass index (overweight and obesity) vs. Normal weight (BMI 18.5-24.9) was evaluated on Late major adverse outcomes (myocardial infarction, stroke, and death) and restenosis. Being overweight or obese was not related to the occurrence of late adverse outcomes, including myocardial infarction, stroke, death, or restenosis, after a carotid endarterectomy.
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