What is the clinical evidence from this study?

Study design: Other. Population: Vessel thrombosis and endothelial denudation. Intervention: Staurosporin vs. Saline. Primary outcome: Vessel thrombosis (p=<0.01).

What does this research mean for the field?

In vivo induction of endothelial apoptosis directly causes endothelial denudation and vessel thrombosis, serving as a critical mechanism in the transition from stable plaques to plaque erosion. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 2026Circulation

In Vivo Induction of Endothelial Apoptosis Leads to Vessel Thrombosis and Endothelial Denudation

Q: What are the key findings of this study?

In vivo induction of endothelial apoptosis with staurosporin significantly increased vessel thrombosis compared to saline (58% vs 8%, P<0.01).

Q: What does this research mean for the field?

In vivo induction of endothelial apoptosis directly causes endothelial denudation and vessel thrombosis, serving as a critical mechanism in the transition from stable plaques to plaque erosion. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This study investigates the role of endothelial apoptosis in vessel thrombosis and endothelial erosion.

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Key result

Endothelial apoptosis induction with staurosporine increases vessel thrombosis to 58% vs 8% with saline.

P<0.01

Why the study?

Does staurosporin-induced endothelial apoptosis cause vessel thrombosis and endothelial denudation in rabbit femoral arteries?

Population

New Zealand White rabbit femoral arteries, including normal and balloon-injured atheromatous arteries

Comparison

Incubation with staurosporin for 30 minutes vs Contralateral artery incubated with saline

Design

Preclinical

Follow-up

3 days

Authors

ÉDÉric DurandCentre de Coopération Internationale en Recherche Agronomique pour le Développement ASAlexandra ScoazecInserm ALAntoine LafontInterventional / Structural Cardiology

Discussion

Member takes

Implication

In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation, highlighting a potential mechanism for plaque erosion and acute coronary syndromes.

Key Points

This study investigates the role of endothelial apoptosis in vessel thrombosis and endothelial erosion.
Segments of New Zealand White rabbit femoral arteries were treated with staurosporin or saline control.
Thrombosis was evaluated angiographically and histologically three days post-treatment.
Immunoreactivities for tissue factor and fibrin were assessed within the thrombus.
Endothelial apoptosis score was significantly higher in staurosporin-treated arteries (2.43±0.30) compared to controls (0.93±0.44, P=0.001).
Vessel thrombosis occurred in 58% of staurosporin-treated arteries (7/12) versus only 8% in saline-treated (P<0.01).
Addition of ZVAD-fmk significantly reduced thrombosis occurrence to 14% (1/7, P=0.04).

Structured PICO

Does staurosporin-induced endothelial apoptosis cause vessel thrombosis and endothelial denudation in rabbit femoral arteries?

Population

In vivo study of New Zealand White rabbit femoral arteries evaluating the role of endothelial apoptosis in vessel thrombosis.

Intervention

Incubation with staurosporin for 30 minutes (with or without ZVAD-fmk 0.1 mmol/L)

Comparator

Contralateral artery incubated with saline

Outcome

Vessel thrombosis and endothelial denudation evaluated angiographically and histologically at 3 dayssurrogate

Main Result

Absolute Event Rate: 58% vs 8%

p-value: p=<0.01

In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation, highlighting a potential mechanism for plaque erosion and acute coronary syndromes.

Cite This Study

Durand et al. (2004) studied Vessel thrombosis and endothelial denudation. Staurosporin vs. Saline was evaluated on Vessel thrombosis (p=<0.01). In vivo induction of endothelial apoptosis with staurosporin significantly increased vessel thrombosis compared to saline (58% vs 8%, P<0.01).

synapsesocial.com/papers/6a6e62c709fb4e44f899ddd4 https://doi.org/10.1161/01.cir.0000130172.62481.90

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Implication

In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation, highlighting a potential mechanism for plaque erosion and acute coronary syndromes.

In Vivo Induction of Endothelial Apoptosis Leads to Vessel Thrombosis and Endothelial Denudation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

In Vivo Induction of Endothelial Apoptosis Leads to Vessel Thrombosis and Endothelial Denudation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider