Key result
High fat diet-induced obesity promoted the quantitative expansion of myeloid progenitors and potentiated inflammation in macrophages derived from these progenitors via a MyD88-dependent mechanism.
Why the study?
Does high fat diet-induced obesity promote myelopoiesis and inflammatory macrophage production from hematopoietic stem cells in mice?
Does high fat diet-induced obesity promote myelopoiesis and inflammatory macrophage production from hematopoietic stem cells in mice?
Diet-induced obesity primes hematopoietic stem cells to increase myeloid progenitor production and generate inflammatory adipose tissue macrophages via a MyD88-dependent mechanism.
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Points to bone marrow in obesity inflammation; leaves open therapeutic targeting in humans.
Singer et al. (2014) studied Diet-induced obesity. High fat diet (HFD) vs. Normal diet (ND, 4.5% fat) was evaluated on Myeloid progenitor expansion and CD11c+ adipose tissue macrophage accumulation. High fat diet-induced obesity promoted the quantitative expansion of myeloid progenitors and potentiated inflammation in macrophages derived from these progenitors via a MyD88-dependent mechanism.
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