March 1, 1975Proceedings of the National Academy of Sciences124 citationsOpen Access

Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material.

SCSisir K. Chattopadhyay WRWallace P. Rowe NTNatalie M. Teich

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Abstract

DNA of the AKR mouse contains a set of murine leukemia virus sequences that are not present in DNA of the NIH Swiss mouse. NIH mice partially congenic for the AKR murine-leukemia-virus-inducing locus Akv-1 contain this set of sequences, and, in a three-point cross segregating for Akv-1 on an NIH background, the sequences segregated with Akv-1. It is concluded that the Akv-1 locus contains viral sequences.

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synapsesocial.com/papers/6a6e6791f44fa9f079dc27d7 https://doi.org/https://doi.org/10.1073/pnas.72.3.906

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