Smoking is associated with an increased risk of acute chest syndrome and pain among adults with sickle cell disease

To the editor: Acute chest syndrome (ACS) is a leading cause of hospitalization and death for people with sickle cell disease (SCD).[1][1] Cigarette smoking has been inconsistently related to an increased risk of ACS in prior studies[2][2],[3][3] and may be one of the few potentially modifiable