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A patient with a haemorrhage in the right mesial frontal lobe exhibited hypokinesia, bradykinesia and a hypometric movement disorder of his contralateral limbs. This movement disorder was characterized by reduced amplitude of otherwise normally formed movements (hypometria). In addition, the left limb hypokinesia improved with placement of the left forelimb into right hemispace (hemispatial motor neglect). We postulate that the hypokinesia, bradykinesia and hypometria were induced by reduction in activation of forebrain dopaminergic and basal ganglion motor systems, which in conjunction with the supplementary motor area are critical for setting the activational level for motor output.
Meador et al. (Wed,) studied this question.