Key result
Endothelial layer removal prevents normal arterial relaxation, demonstrating endothelial release of essential vasoactive substances.
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More than a quarter of a century ago Robert Furchgoldltt demonstrated that removing the endothelial layer from the isolated aorta of a rabbit prevents normal relaxation in response to acetylcholine.1 The ability of the endothelium to elicit relaxation was soon extended to more relevant physiological stimuli (adenosine triphosphate, bradykinin and serotonin).2,3 The endothelial cells cause arterial relaxation by releasing a powerful vasoactive substance(s) that diffuses to the underlying layers of vascular smooth muscle and thus was termed endotheli
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Paul M. Vanhoutte (2008) conducted a review in Endothelial Dysfunction. Removal of the endothelial layer prevents normal arterial relaxation in response to stimuli, demonstrating that endothelial cells release powerful vasoactive substances.
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