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January 19, 2024Clinical Kidney JournalOpen Access

Potentially modifiable factors associated with health-related quality of life among people with chronic kidney disease: baseline findings from the National Unified Renal Translational Research Enterprise CKD (NURTuRE-CKD) cohort

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Identify potentially modifiable factors associated with health-related quality of life among chronic kidney disease patients.
Baseline data collection from 2996 participants in the NURTuRE-CKD cohort study across nephrology centres.
Measured health-related quality of life using EQ-5D-5L and assessed various sociodemographic, clinical, and biochemical factors.
Used multivariable mixed effects regression models to analyze associations between identified factors and health-related quality of life.
74.4% of participants reported problems in at least one EQ-5D-5L dimension.
Independent associations found between poorer HRQoL and factors like obesity (β −0.037, P=0.001), HADS depression score ≥8 (β −0.159, P<0.001), and anxiety score ≥8 (β −0.090, P<0.001).
Prescription of RAS inhibitors linked to fewer mobility and usual activity problems.

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Randomized trial identifies factors influencing health-related quality of life in chronic kidney disease, suggesting intervention opportunities.

Phillips et al. (2024) studied this question.

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Randomized trial identifies factors influencing health-related quality of life in chronic kidney disease, suggesting intervention opportunities.