Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines

Pentafluorosulfanyl power! The SF5 group—a novel substituent with striking physicochemical properties—was used as building block for trypanothione reductase (TR) inhibitors and compared to its CF3 and C(CH3)3 relatives. The high in vitro activities of these derivatives against Trypanosoma brucei rhodesiense as well as against Plasmodium falciparum supports the suitability of SF5 as a component of drug-like compounds.