Key result
Higher third-trimester GPIHBP1 is linked to lower neonatal birth weight and umbilical pO2 in GDM.
Why the study?
With the increasing prevalence of GDM, circulating GPIHBP1 levels during pregnancy and their associations with hypertriglyceridaemia and perinatal outcomes of GDM were evaluated.
Are circulating GPIHBP1 levels associated with perinatal outcomes in pregnant women with gestational diabetes mellitus?
Observational (n=33)
No
Are circulating GPIHBP1 levels associated with perinatal outcomes in pregnant women with gestational diabetes mellitus?
Effect estimate: r=-0.636
p-value: p=0.026
Circulating GPIHBP1 levels in the third trimester are negatively correlated with neonatal birth weight percentile and umbilical venous pO2 in women with gestational diabetes mellitus, suggesting a potential role as a biomarker for placental function.
GPIHBP1 levels in third-trimester GDM correlate with neonatal birth weight and pO2; hypothesis-generating pilot data requiring prospective validation before any clinical role.
Introduction The prevalence of gestational diabetes mellitus (GDM) is significantly increasing. Hyperglycaemia and dyslipidaemia have been demonstrated to contribute to endothelial dysfunction linked to foetal–placental circulation. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) is crucial for the lipolytic processing of TG-rich lipoproteins through the anchoring of lipoprotein lipase (LPL). In this study, circulating GPIHBP1 levels during pregnancy were evaluated, and their associations with hypertriglyceridaemia and the perinatal outcomes of GDM were evaluated. Methods This study included 12 pregnant women with GDM and 21 pregnant women with normal glucose tolerance (NGT). Results No significant differences in obstetrical outcomes were detected between the two groups. In participants with NGT, circulating GPIHBP1 levels were markedly lower in the 3rd trimester than in the 2nd trimester and at delivery. In women with GDM, circulating GPIHBP1 levels were unchanged during the 3rd trimester, and circulating GPIHBP1 levels throughout the 3 rd trimester were negatively correlated with neonatal birth weight percentile and umbilical venous pO 2 (ρ=-0.636, p=0.026; ρ=-0.657, p=0.020). Discussion Our findings suggest a possible association between circulating GPIHBP1 levels and perinatal outcomes in patients with GDM.
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Watanabe et al. (2025) conducted an observational in Gestational diabetes mellitus (n=33). Circulating GPIHBP1 levels was evaluated on Correlation between circulating GPIHBP1 levels in the 3rd trimester and neonatal birth weight percentile in women with gestational diabetes mellitus (r=-0.636, p=0.026). In women with gestational diabetes mellitus, circulating GPIHBP1 levels during the third trimester were negatively correlated with neonatal birth weight percentile (r=-0.636) and umbilical venous pO2 (r=-0.657).
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