Key result
Lepirudin potentiates phenprocoumon effects on PiCT, whereas other anticoagulants show distinct linear additive interactions.
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Prothrombinase-induced clotting time (PiCT) is a clotting-time test for heparins and direct thrombin inhibitors to reduce drawbacks of aPTT. Effects of the direct thrombin inhibitors lepirudin, argatroban, melagatran and of unfractionated heparin (UFH) were investigated in normal and oral anticoagulant plasma samples. Lepirudin showed potentiating interferences with phenprocoumon effects. Melagatran, argatroban and UFH delivered distinct linear additive effects in both plasma sample groups. PiCT ratio reduces differences between both groups with UFH, and argatroban inhibitor-receptor-binding mode plays a role in interaction patterns.
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Fenyvesi et al. (2002) studied this question. Direct thrombin inhibitors and UFH in phenprocoumon plasma vs. Normal plasma samples was evaluated on Prothrombinase-induced clotting time (PiCT). Lepirudin showed potentiating interferences with phenprocoumon on PiCT in plasma samples, while melagatran, argatroban, and unfractionated heparin delivered distinct linear additive effects.
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