Key result
Leiotonin C is responsible for Ca2+ binding of the aortic thin filament at low Ca2+ concentrations, indicating that the physiological Ca2+ binding protein is leiotonin rather than calmodulin.
Population
Bovine aorta smooth muscle (leiotonin and actin complex)
Comparison
Ca2+ and Sr2+ binding assays, manipulation of… vs Actin filament without leiotonin; reconstituted…
Design
Preclinical
Authors
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Hypothesis-generating for vascular Ca2+ regulation; leaves open any clinical relevance pending higher-level evidence.
This basic science study demonstrates that leiotonin, rather than calmodulin, is the primary Ca2+ binding protein regulating vascular smooth muscle contraction under physiological conditions.
Hirata et al. (1980) studied Vascular smooth muscle physiology. Leiotonin C removal and replacement vs. Actin filament without leiotonin was evaluated on Ca2+ binding capacity and superprecipitation. Leiotonin C is responsible for Ca2+ binding of the aortic thin filament at low Ca2+ concentrations, indicating that the physiological Ca2+ binding protein is leiotonin rather than calmodulin.
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