Key result
A multiscale computational model coupling electrophysiological and mechanical models successfully reproduced healthy cardiovascular behavior, preload variations, and ventricular failure.
A novel multiscale computational model successfully links cellular-level sarcomere mechanics to global ventricular hemodynamics in both healthy and failing states.
Multiscale CVS model links sarcomere mechanics to ventricular hemodynamics; leaves open clinical translation pending experimental validation.
A multiscale model of the cardiovascular system (CVS) is presented. Hemodynamics is described by a lumped parameter model, while heart contraction is described at the cellular scale. An electrophysiological model and a mechanical model were coupled and adjusted so that the pressure and volume of both ventricles are linked to the force and length of a half-sarcomere. Particular attention was paid to the extremal values of the sarcomere length, which must keep physiological values. This model is able to reproduce healthy behavior, preload variations experiments, and ventricular failure.
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Kosta et al. (2015) studied this question. Multiscale computational model was evaluated. A multiscale computational model coupling electrophysiological and mechanical models successfully reproduced healthy cardiovascular behavior, preload variations, and ventricular failure.
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