Twenty-four non-clonally related enterobacterial isolates producing the emerging CTX-M-type extended-spectrum β-lactamases were recovered from several countries including France, India, Poland, and Turkey. They had been isolated from 2000 to 2003. β-Lactamases CTX-M-2, CTX-M-3, CTX-M-10, CTX-M-14 and CTX-M-15 were identified. Most of the isolates produced β-lactamase CTX-M-15. Insertion sequence ISEcp1 was found upstream of blaCTX-M-3, blaCTX-M-10, blaCTX-M-14 and blaCTX-M-15 genes. A sequence similar to the inverted right repeat of ISEcp1 was identified downstream of blaCTX-M-3, blaCTX-M-10 and blaCTX-M-15genes suggesting the mobilization of these β-lactamase genes by transposition events. In addition, Orf513 was identified upstream of the blaCTX-M-2 gene. This work further underlined widespread of blaCTX-M-15gene associated with ISEcp1.
No takes yet. Share an insight, caveat, or question.
Lartigue et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: