Key result
The highest quartile of neutrophil-to-lymphocyte ratio was significantly associated with increased odds of subclinical diabetic cardiomyopathy compared to the lowest quartile in patients with type 2 diabetes (OR 14.32).
Why the study?
Subclinical diabetic cardiomyopathy occurs frequently in asymptomatic T2DM patients, and an association between the immune system and diabetic cardiomyopathy with effective biomarkers has been demonstrated.
Does a higher neutrophil:lymphocyte ratio predict subclinical diabetic cardiomyopathy in adults with Type 2 diabetes mellitus?
Cross-Sectional (n=507)
No
Does a higher neutrophil:lymphocyte ratio predict subclinical diabetic cardiomyopathy in adults with Type 2 diabetes mellitus?
Odds Ratio: 14.32 (95% CI 2.92–70.31)
p-value: p=<0.001
A higher neutrophil to lymphocyte ratio is strongly associated with the presence of subclinical diabetic cardiomyopathy in asymptomatic patients with type 2 diabetes, suggesting its potential utility as a screening biomarker.
NLR association with subclinical DCM in T2D is hypothesis-generating; prospective validation required before any clinical use.
BACKGROUND: Subclinical diabetic cardiomyopathy (DCM) occurs frequently in asymptomatic subjects with Type 2 diabetes mellitus (T2DM). The direct association between the immune system and DCM with effective biomarkers has been demonstrated in previous studies. METHODS: Five hundred seven subjects with T2DM were recruited from April 2018 to October 2019 and divided into T2DM with cardiac dysfunction (DCM) group and T2DM without cardiac dysfunction (non-DCM) group. The relationship between the quartiles of Neutrophil: lymphocyte ratio (NLR) and subclinical DCM was evaluated by using adjusted logistic regression models.(covariates: age, sex, BMI, duration of diabetes, and hyperlipidemia). RESULTS: Blood NLR was significantly upregulated in DCM group compared to non-DCM group (P = 0.05). Then the adjusted odds ratio (95% CI) of the highest NLR quartile was 14.32 (2.92-70.31) compared with the lowest quartile of NLR after multiple adjusted (P < 0.001). However, there was no significant relation between neutrophil and lymphocyte counts and the occurrence of DCM in T2DM patients. CONCLUSIONS: This study demonstrated that NLR was associated with the occurrence of subclinical DCM, suggesting that NLR may be a biomarker for predicting DCM with effectiveness and accuracy. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR1900027080) . Registered 30 October 2019. Retrospectively registered: www.medresman.org.
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Huang et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus and subclinical diabetic cardiomyopathy (n=507). Neutrophil: lymphocyte ratio (NLR) vs. Lowest quartile of NLR was evaluated on Subclinical diabetic cardiomyopathy (DCM) (OR 14.32, 95% CI 2.92-70.31, p=<0.001). The highest quartile of neutrophil-to-lymphocyte ratio was significantly associated with increased odds of subclinical diabetic cardiomyopathy compared to the lowest quartile in patients with type 2 diabetes (OR 14.32).
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