Previous investigations dealing with the histopathological changes induced by radiation in the normal thyroid gland may be grouped according to whether the radiation was applied externally by X-ray or internally by either the implantation of radium needles or the administration of radioactive iodine. The early studies dealing with X-ray and radium needle implants, which have been reviewed by Warren (1943), have served to emphasize the resistance of the normal thyroid gland to radiation. Destruction of variable amounts of the normal thyroid gland by the administration of radioactive iodine has been reported: in the dog, by Hamilton and Lawrence (1942) and by Hamilton (1942); in the rabbit, by Hamilton and Lawrence (1942); in the adult rat, by Findlay and Leblond (1948); in the new-born rat, by Goldberg and Chaikoff (1949); and in the mouse, by Gorbman (1947, 1949). The purpose of the present investigation was to provide, in some detail, a continuous picture of the progressive changes induced in the thyroid gland by internal, ionizing radiation.
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GOLDBERG et al. (1950) studied this question.