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Experimentally damaged leaves of Cucurbita moschata mobilize substances to the damaged region within 40 minutes. These substances stimulate feeding by Acalymma vittata (Coleoptera: Chrysomelidae) and inhibit feeding by Epilacha tredecimnotata (Coleoptera: Coccinelidae). Under natural conditions, Epilachna cuts a circular trench in the leaf before feeding on the encircled leaf material, thus preventing mobilization of the deterrent substances to the feeding area.
Carroll et al. (Fri,) studied this question.