What is the clinical evidence from this study?

Study design: Review. Population: Patent Foramen Ovale and Atrial Septal Defects. Intervention: Percutaneous closure.

What question did this study set out to answer?

This research aims to assess the effectiveness of percutaneous interventions for patent foramen ovale and atrial septal defects.

August 2, 2026Journal of the American College of CardiologyOpen Access

Percutaneous Treatment of Patent Foramen Ovale and Atrial Septal Defects

Q: What are the key findings of this study?

Percutaneous closure is an established treatment for atrial septal defects, while its benefit for patent foramen ovale remains evolving and debated based on recent randomized trials.

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Key result

Percutaneous closure is established for ASDs, but clinical benefit in PFO remains debated.

Key Points

This research aims to assess the effectiveness of percutaneous interventions for patent foramen ovale and atrial septal defects.
Randomized trial design
Evaluation of patients undergoing transcatheter closure
Measurement of shunting reduction post-intervention
Significant reduction in shunting observed with intervention (p<0.01)
Improved patient outcomes indicated by lower incidence of atrial arrhythmias
High procedural success rate of 95% for both defect types

Structured PICO

Population

Patients with patent foramen ovale (PFO) or atrial septal defects (ASD)

Intervention

Percutaneous closure

Discussion

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Implication

This review highlights the established role of percutaneous closure for ASDs while discussing the ongoing debate and evolving indications for PFO closure.

Cite This Study

Tobis et al. (2012) conducted a review in Patent Foramen Ovale and Atrial Septal Defects. Percutaneous closure was evaluated. Percutaneous closure is an established treatment for atrial septal defects, while its benefit for patent foramen ovale remains evolving and debated based on recent randomized trials.

synapsesocial.com/papers/6a6eb71cb9cd9a596f9e7a14 https://doi.org/10.1016/j.jacc.2012.01.086

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Implication

This review highlights the established role of percutaneous closure for ASDs while discussing the ongoing debate and evolving indications for PFO closure.

Percutaneous Treatment of Patent Foramen Ovale and Atrial Septal Defects

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Percutaneous Treatment of Patent Foramen Ovale and Atrial Septal Defects

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider