Effect of Thrombomodulin Alfa on Disseminated Intravascular Coagulation in Patients with Lung Cancer

Figures

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  Figure 1.. Relationship between dose of thrombomodulin alfa (TM-α) and clinical outcome of disseminated intravascular coagulation (DIC) in patients with or without lung cancer. The dose of TM-α per kilogram body weight (BW) was calculated. A significant difference was observed between the survivors and non-survivors with lung cancer.

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  Figure 2.. Relationship between vital signs and clinical outcome of DIC with or without lung cancer. The initial body temperature and heart rates at the time of diagnosis of DIC are shown in A and B, respectively. A significant difference in body temperature was observed between the survivors and non-survivors without lung cancer.

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  Figure 3.. Relationship between laboratory data and clinical outcome of DIC with or without lung cancer. The initial white blood cell (WBC) count and serum C-reactive protein (CRP) level at the time of diagnosis of DIC are shown in A and B, respectively. A significant difference in CRP was observed between the survivors and non-survivors with lung cancer and between the survivors with lung cancer and non-survivors without lung cancer.

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  Figure 4.. Relationship between blood coagulation factors and clinical outcome of DIC in patients with or without lung cancer. The initial platelet count, prothrombin time-international normalized ratio (PT-INR), and serum levels of fibrinogen degradation products (FDP) and D-dimer at the time of the diagnosis of DIC are shown in A, B, C, and D, respectively. A significant difference in PT-INR was observed between the survivors and non-survivors with lung cancer and between the survivors with lung cancer and non-survivors without lung cancer.

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  Figure 5.. Relationship between blood coagulation factor and time to recovery from DIC in the recovery group. The initial platelet count, PT-INR, and serum levels of FDP and D-dimer at the time of the diagnosis of DIC are shown in A, B, C, and D, respectively. Open and closed circles represent the non-lung cancer and lung cancer groups, respectively. With the regression line, broken and solid lines represent the non-lung cancer and lung cancer groups, respectively. A significant negative correlation in the platelet count was observed in patients without lung cancer.