Key result
Increased hand grip strength was significantly correlated with decreased augmentation index (r = 0.437, P<0.001), but not with brachial-ankle pulse wave velocity or carotid intima medial thickness.
Why the study?
Hand grip strength is inversely associated with cardiovascular events, but the exact mechanism is unestablished, prompting evaluation of whether arterial stiffness mediates this association.
Does hand grip strength correlate with arterial stiffness parameters in a general adult cohort?
Cohort (n=1,508)
Does hand grip strength correlate with arterial stiffness parameters in a general adult cohort?
Hand grip strength is inversely correlated with central arterial stiffness (augmentation index), suggesting a potential mechanism for its known association with cardiovascular events.
Answers are grounded in this paper and cite their sources.
May aid cardiovascular risk stratification via hand grip strength; leaves open arterial stiffness mediation of events.
BACKGROUND: Hand grip strength (HGS) has been associated with cardiovascular events. However, the exact mechanism responsible for the inverse association between HGS and cardiovascular events has not been established. The aim of this study was to assess whether arterial stiffness mediates this association. METHODS: We studied 1508 participants (age; 60 ± 5, men; 47.5%) from the Ansan cohort of the Korean Genome Epidemiology Study. Participants were assessed for various parameters of arterial stiffness as well as HGS. The augmentation index (AIx) and brachial-ankle pulse wave velocity (baPWV) were evaluated by using an applanation tonometer and automated waveform analyzer, respectively. Carotid intima medial thickness (IMT) was measured by B-mode ultrasonogram with a 7.5-MHz linear array transducer. HGS was evaluated using a Jamar dynamometer. RESULTS: With increased grip strength, AIx decreased (r = 0.437, P < 0.001). baPWV (r = 0.044, P = 0.107) and carotid IMT (r = 0.005, P = 0.856) had no significant correlation with grip strength. This trend was consistently observed regardless of hypertension, but was more pronounced in participants with hypertension. CONCLUSION: HGS was significantly correlated with AIx, but not with baPWV and carotid IMT. Our findings suggest that central arterial stiffness could mediate the association between HGS and cardiovascular events.
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Kim et al. (2021) reported a cohort. Hand grip strength was evaluated on Augmentation index (AIx) (r = 0.437, p=<0.001). Increased hand grip strength was significantly correlated with decreased augmentation index (r = 0.437, P<0.001), but not with brachial-ankle pulse wave velocity or carotid intima medial thickness.
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