Key result
Indomethacin may be useful in managing elevated intracranial pressure following severe head injury by reducing cerebral blood flow and decreasing cerebral edema.
Why the study?
Does indomethacin reduce elevated intracranial pressure in patients with severe head injury?
Does indomethacin reduce elevated intracranial pressure in patients with severe head injury?
Indomethacin may be useful in managing elevated intracranial pressure following severe head injury by reducing cerebral blood flow and edema.
Indomethacin may aid refractory ICP in head injury; leaves open need for RCTs to confirm role and safety.
Elevated intracranial pressure occurs frequently in patients with severe head injury. A number of studies in recent years suggest that indomethacin may be useful in the management of elevated intracranial pressure. Indomethacin acts primarily by reducing cerebral blood flow and decreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cerebral blood flow, brain edema, and intracranial pressure. The pharmacology of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.
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Harrigan et al. (1997) conducted a review in Elevated intracranial pressure in severe head injury. Indomethacin was evaluated. Indomethacin may be useful in managing elevated intracranial pressure following severe head injury by reducing cerebral blood flow and decreasing cerebral edema.
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