Population
15 anaesthetised cats (12 under chloralose, 3 under pentobarbitone)
Comparison
Systemic hypoxia vs Normoxia and/or prevented blood pressure changes
Design
Preclinical
Authors
Loading...
Hypoxic pial dilatation varies with BP in this animal model; leaves open local PO2 versus chemoreflex mechanisms in cerebral autoregulation.
Pial arterial dilatation in response to systemic hypoxia is significantly modulated by concurrent changes in blood pressure, suggesting a local effect of lowered PO2 rather than a chemoreflex component.
Craigen et al. (1981) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: