Population
Rats anaesthetized with Saffan (n=17 for repeated exposure protocol)
Comparison
Systemic hypoxia vs Control periods (30 min)
Design
Preclinical
Authors
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Graded hypoxic vasomotor responses vary by vessel order and severity in rodent muscle; leaves open translation to human perfusion or clinical hypoxia.
Systemic hypoxia induces heterogeneous and graded diameter changes in skeletal muscle microvessels, which vary depending on the severity and repetition of the hypoxic stimulus.
Mian et al. (1991) studied this question.
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