Key result
Acclimation to chronic hypoxia (12% O2) for 7 to 18 days induced arteriolar remodelling and angiogenesis in rat skeletal muscle, increasing the number of small arterioles.
Population
Rats (7CH, 18CH, 7N, 18N groups)
Comparison
Exposure to 12% O2 in a hypoxic chamber for 7 or… vs Age-matched normoxic rats breathing air
Design
Preclinical
Follow-up
7 or 18 days
Authors
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Hypoxia-induced arteriolar remodeling remains preclinical in rats; leaves open translation to human vascular adaptation in chronic disease.
Acclimation to chronic hypoxia in rats induces arteriolar remodeling and angiogenesis in skeletal muscle, enhancing vascular conductance and oxygen delivery capacity.
Smith et al. (1999) studied Chronic hypoxia. Chronic hypoxia vs. Normoxia (air) was evaluated on Muscle vascular conductance and arteriolar remodelling. Acclimation to chronic hypoxia (12% O2) for 7 to 18 days induced arteriolar remodelling and angiogenesis in rat skeletal muscle, increasing the number of small arterioles.
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