Key result
Chronic hypoxia significantly increased the percentage of developing terminal arterioles in rat skeletal muscle compared to controls (70.7% vs 29.2%; p < 0.05).
Population
Rats (n=8 animals, 4 per group, 8 muscles per group)
Comparison
Chronic exposure to 10% oxygen for 18 +/- 3.6 days vs Weight-matched control rats
Design
Preclinical
Follow-up
18 +/- 3.6 days
Authors
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Hypothesis-generating for hypoxia-induced arteriolar remodeling; human validation required before clinical translation.
Absolute Event Rate: 70.7% vs 29.2%
p-value: p=< 0.05
Chronic hypoxia stimulates significant remodeling of both arcade and transverse arteriolar networks in skeletal muscle, increasing terminal arteriolar development and loop formation.
Price et al. (1998) studied Chronic hypoxia (n=8). Chronic hypoxia vs. Weight-matched controls was evaluated on Percentage of terminal arteriolar endings positive for smooth muscle alpha-actin but negative for smooth muscle myosin heavy chain (p=< 0.05). Chronic hypoxia significantly increased the percentage of developing terminal arterioles in rat skeletal muscle compared to controls (70.7% vs 29.2%; p < 0.05).
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