Key result
Chronic ischaemia from iliac artery ligation attenuated arteriole dilation to bradykinin (p<0.01) and reversed acetylcholine responses from dilation (+29%) to constriction (-17%) at 2 weeks.
Why the study?
Does chronic ischaemia alter the reactivity of small arterioles in rat skeletal muscle?
Population
Rat model of chronic hind limb ischaemia (unilateral iliac artery ligation)
Comparison
Chronic ischaemia vs Control (non-ischaemic)
Design
Preclinical
Follow-up
5 weeks
Authors
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May limit revascularization benefits in PAD; hypothesis-generating for microcirculatory-targeted therapies.
Does chronic ischaemia alter the reactivity of small arterioles in rat skeletal muscle?
Absolute Event Rate: -17% vs 29%
p-value: p=< 0.01
Chronic ischaemia induces early endothelial dysfunction and later vascular smooth muscle impairment in skeletal muscle microcirculation, which could limit the benefits of revascularization interventions.
Kelsall et al. (2001) studied chronic hind limb ischaemia. unilateral iliac artery ligation vs. control was evaluated on diameter changes to topical application of endothelium-dependent and endothelium-independent agonists (p=< 0.01). Chronic ischaemia from iliac artery ligation attenuated arteriole dilation to bradykinin (p<0.01) and reversed acetylcholine responses from dilation (+29%) to constriction (-17%) at 2 weeks.
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