Why the study?
Does denervation impair microcirculatory recovery (arteriolar diameters and flow patterns) following ischemia in skeletal muscle?
Population
12 rats (isolated rat cremaster muscle model), divided into two groups of six (innervated and denervated).
Comparison
Denervation of the skeletal muscle prior to 4… vs Innervated skeletal muscle subjected to 4 hours…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Denervation may impair post-ischemic microcirculatory recovery in muscle; leaves open clinical relevance for flap outcomes in reconstructive surgery.
Does denervation impair microcirculatory recovery (arteriolar diameters and flow patterns) following ischemia in skeletal muscle?
Denervation of skeletal muscle impairs microcirculatory recovery and increases the incidence and duration of nonflowing vessels following an ischemic insult.
Wang et al. (1995) studied this question.
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