Population
Anesthetized rats (cremaster muscle model)
Comparison
Increasing intravascular pressure via an… vs Baseline/resting state
Design
Preclinical
Authors
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May explain pressure-related hypoperfusion in skeletal muscle; leaves open translation to human microvascular disease.
Demonstrates a potent, pressure-dependent myogenic mechanism in small arterioles that overrides local metabolic control in resting skeletal muscle.
Meininger et al. (1987) studied this question.
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