Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1998HypertensionOpen Access

Nitric Oxide Opposes Myogenic Pressure Responses Predominantly in Large Arterioles In Vivo

View Full Paper
Ask AI
Bookmark
Share

Population

30 anesthetized (pentobarbital) hamsters prepared for intravital microscopy of the cremaster muscle

Comparison

Intravenous infusion of norepinephrine or… vs Baseline conditions or control animals without…

Design

Preclinical

Authors

CWCor de WitUniversity of LübeckBJBernhard JahrbeckUniversity of LübeckCSChristian SchäferJohannes Gutenberg University Mainz

Discussion

Loading...

Member takes

Implication

Indicates size-dependent NO opposition to myogenic tone; leaves open relevance for human hypertension.

Structured PICO

P
Population
30 anesthetized (pentobarbital) hamsters prepared for intravital microscopy of the cremaster muscle
I
Intervention
Intravenous infusion of norepinephrine (0.5 nmol/min) or angiotensin II, and local pressure manipulation, with or without NO synthase inhibitor N(G)-nitro-L-arginine (L-NNA, 30 micromol/L)
C
Comparator
Baseline conditions or control animals without L-NNA treatment
O
Outcome
Changes in inner diameter of small arterioles (36 to 65 microm) and large arterioles (65 to 127 microm)surrogate

Nitric oxide plays a crucial role in opposing myogenic vasoconstriction predominantly in large arterioles, which may be a key mechanism in controlling total peripheral vascular resistance.

Cite This Study

Wit et al. (1998) studied this question.

synapsesocial.com/papers/6a75978d20ccc22d0a67a66bhttps://doi.org/10.1161/01.hyp.31.3.787
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential sensitivity of arteriolar alpha 1- and alpha 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction.1991 · 136 citations
  2. 2Characteristics and origin of myogenic response in isolated gracilis muscle arterioles1994 · 97 citations
  3. 3Vasoconstriction is amplified by autoregulation during vasoconstrictor-induced hypertension1988 · 37 citations
  4. 4EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries1991 · 234 citations
  5. 5Autoregulation during pressor response elevates wall shear rate in arterioles1996 · 14 citations