July 1, 1997AJP Heart and Circulatory Physiology

Endothelium-derived nitric oxide limits sympathetic neurogenic constriction in intestinal microcirculation

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Population

Superfused small intestine of the rat, specifically first-order arterioles (1A)

Comparison

Passage of a CO2 embolus through the 1A lumen to… vs Baseline responses before passage of the embolus

Design

Preclinical

Authors

GNGeoffrey P. NaseWest Virginia University MBM. A. BoegeholdWest Virginia University

Discussion

Member takes

Implication

Endothelial NO attenuates sympathetic constriction in intestinal microvessels; hypothesis-generating for embolization-related dysfunction pending higher-species confirmation.

Structured PICO

Population

Superfused small intestine of the rat, specifically first-order arterioles (1A)

Intervention

Passage of a CO2 embolus (or N2 embolus) through the 1A lumen to inhibit endothelial function

Comparator

Baseline responses before passage of the embolus

Outcome

Arteriolar diameter responses to perivascular sympathetic nerve stimulation (at 3, 8, and 16 Hz) and directly applied norepinephrinesurrogate

Nitric oxide of endothelial origin plays an important role in attenuating sympathetic neurogenic constriction in the intestinal microvasculature.

Cite This Study

Nase et al. (1997) studied this question.

synapsesocial.com/papers/6a6f99f92fdcb5703edb4b86 https://doi.org/10.1152/ajpheart.1997.273.1.h426

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Implication

Endothelial NO attenuates sympathetic constriction in intestinal microvessels; hypothesis-generating for embolization-related dysfunction pending higher-species confirmation.