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October 1, 2001HypertensionOpen Access

An Endothelium-Derived Hyperpolarizing Factor–Like Factor Moderates Myogenic Constriction of Mesenteric Resistance Arteries in the Absence of Endothelial Nitric Oxide Synthase–Derived Nitric Oxide

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Population

Third-order mesenteric arteries (approximately 200 micrometer) from wild-type and eNOS knockout mice

Comparison

Endothelium removal, L-NAME, indomethacin, or… vs Intact endothelium or untreated arteries

Design

Preclinical

Authors

RSRamona S. ScotlandQueen Mary University of LondonSCSharmila D. ChauhanDoon UniversityPVPatrick VallanceThe University of Melbourne

Discussion

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Implication

Hypothesis-generating in eNOS knockout mice; leaves open EDHF relevance to human hypertension.

Structured PICO

P
Population
Third-order mesenteric arteries (approximately 200 micrometer) from wild-type and eNOS knockout mice
I
Intervention
Endothelium removal, L-NAME (300 micromol/L), indomethacin (5 micromol/L), or blockade of EDHF-like mechanisms (apamin with charybdotoxin, Ba2+ with ouabain, or 18alpha-glycyrrhetinic acid)
C
Comparator
Intact endothelium or untreated arteries
O
Outcome
Myogenic constriction (internal diameter recorded over a pressure range of 10 to 80 mm Hg)surrogate

In eNOS knockout mice, an endothelium-derived hyperpolarizing factor compensates for the lack of nitric oxide to modulate myogenic tone in mesenteric resistance arteries.

Cite This Study

Scotland et al. (2001) studied this question.

synapsesocial.com/papers/6a6f9aaaac440176ef284446https://doi.org/10.1161/hy1001.092651
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characteristics and origin of myogenic response in isolated mesenteric arterioles1992 · 103 citations
  2. 2Flow regulation of ecNOS and Cu/Zn SOD mRNA expression in porcine coronary arterioles1999 · 97 citations
  3. 3Enhanced Release of Prostaglandins Contributes to Flow-Induced Arteriolar Dilation in eNOS Knockout Mice1999 · 185 citations
  4. 4Nitric Oxide Opposes Myogenic Pressure Responses Predominantly in Large Arterioles In Vivo1998 · 70 citations
  5. 5Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery1997 · 214 citations