March 1, 2000AJP Heart and Circulatory Physiology

In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF

View Full Paper

Ask AI

Bookmark

Population

Isolated, cannulated, and pressurized arterioles of gracilis muscle from male eNOS-KO and wild-type (WT) mice

Comparison

Acetylcholine (10-10 M) with or without inhibitors vs Wild-type (WT) mice arterioles

Design

Preclinical

Authors

AHAn HuangFirst Affiliated Hospital of Jiangxi Medical College DSDong SunShanxi Medical University CSCarolyn J. SmithUniversity of California, Riverside

Discussion

Member takes

Implication

Animal evidence of EDHF compensation in eNOS deficiency; leaves open human microvascular relevance.

Structured PICO

Population

Isolated, cannulated, and pressurized arterioles of gracilis muscle from male eNOS-KO and wild-type (WT) mice

Intervention

Acetylcholine (ACh) (10(-9)-10(-7) M) with or without inhibitors (L-NNA, indomethacin, clotrimazole, miconazole, high K+, iberiotoxin)

Comparator

Wild-type (WT) mice arterioles

Outcome

Arteriolar dilation response to acetylcholinesurrogate

In the absence of endothelial nitric oxide synthase, endothelium-derived hyperpolarizing factor (EDHF) synthesized via cytochrome P-450 compensates to mediate acetylcholine-induced vasodilation in skeletal muscle arterioles.

Cite This Study

Huang et al. (2000) studied this question.

synapsesocial.com/papers/6a6f7c448031ec7bb1dbc5d3 https://doi.org/10.1152/ajpheart.2000.278.3.h762

View Full Paper

Ask AI

Bookmark

March 1, 2000AJP Heart and Circulatory Physiology

In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF

View Full Paper

Ask AI

Bookmark

Population

Isolated, cannulated, and pressurized arterioles of gracilis muscle from male eNOS-KO and wild-type (WT) mice

Comparison

Acetylcholine (10-10 M) with or without inhibitors vs Wild-type (WT) mice arterioles

Design

Preclinical

Authors

AHAn HuangFirst Affiliated Hospital of Jiangxi Medical College DSDong SunShanxi Medical University CSCarolyn J. SmithUniversity of California, Riverside

Discussion

Member takes

Implication

Animal evidence of EDHF compensation in eNOS deficiency; leaves open human microvascular relevance.

Structured PICO

Population

Isolated, cannulated, and pressurized arterioles of gracilis muscle from male eNOS-KO and wild-type (WT) mice

Intervention

Acetylcholine (ACh) (10(-9)-10(-7) M) with or without inhibitors (L-NNA, indomethacin, clotrimazole, miconazole, high K+, iberiotoxin)

Comparator

Wild-type (WT) mice arterioles

Outcome

Arteriolar dilation response to acetylcholinesurrogate

Cite This Study

Huang et al. (2000) studied this question.

synapsesocial.com/papers/6a6f7c448031ec7bb1dbc5d3 https://doi.org/10.1152/ajpheart.2000.278.3.h762

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark