Why the study?
Does chronic electrical stimulation improve capillary supply and correct abnormal vasoreactivity in limb skeletal muscle post-MI in a rat model?
Population
24 rats. MI size approximately 30% of the left ventricle.
Comparison
Chronic electrical stimulation of the extensor… vs MI alone (no stimulation) and healthy controls.
Design
Preclinical
Follow-up
6 +/- 1 days
Authors
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Does not support clinical translation post-MI; hypothesis-generating for selective microvascular effects in animal models.
Does chronic electrical stimulation improve capillary supply and correct abnormal vasoreactivity in limb skeletal muscle post-MI in a rat model?
In a rat model of MI, chronic electrical stimulation of skeletal muscle normalizes resting arteriolar diameter and increases capillarization but does not correct abnormal vasoreactivity.
Thomas et al. (1999) studied this question.
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