Key result
Increasing oxygen concentration progressively decreases arteriolar diameter, velocity, and volume flow in isolated muscle.
Why the study?
Does increasing oxygen concentration affect arteriolar dimensions and blood flow in cat sartorius muscle?
Population
Isolated autoperfused cat sartorius muscle
Comparison
Gas mixtures containing 5, 10, or 20% O2 in N2… vs 0% O2 in N2
Design
Preclinical
Authors
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Oxygen-induced arteriolar constriction and flow reduction in cat muscle should not guide clinical oxygen use; leaves open size-dependent sensitivity in skeletal muscle microcirculation.
Does increasing oxygen concentration affect arteriolar dimensions and blood flow in cat sartorius muscle?
Increasing oxygen concentration leads to a reduction in arteriolar diameter and volume flow in cat sartorius muscle, with small arterioles showing a greater fall in volume flow but similar percentage reduction in diameter compared to large arterioles.
Sullivan et al. (1981) studied this question. Oxygen vs. 0% O2 was evaluated on Arteriolar internal diameter, dual-slit velocity, and volume flow. Increasing oxygen concentration from 0 to 10% and then to 20% progressively decreased arteriolar diameter, dual-slit velocity, and volume flow in isolated cat sartorius muscle.
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