Population
Anaesthetized rats (spinotrapezius muscle model)
Comparison
Topical application of phentolamine or sotalol… vs Hypoxia before antagonist application
Design
Preclinical
Authors
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Animal findings on adrenoreceptor modulation of hypoxic vessels do not inform clinical practice; leaves open mechanistic translation to human hypoxia.
In a rat model, systemic hypoxia induces skeletal muscle vascular diameter changes that are partially mediated by alpha- and beta-adrenoreceptors responding to sympathetic nerve activity and circulating catecholamines.
Mian et al. (1991) studied this question.
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