January 1, 1999The Journal of PhysiologyOpen Access

Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors

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Population

Anaesthetized rats (n=23)

Comparison

Systemic hypoxia and adenosine before and after… vs Baseline responses before antagonist…

Design

Preclinical

Authors

PBPhilip BryanPhilips (Finland)JMJanice M. MarshallUniversity of Birmingham

Discussion

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Implication

Animal data prioritize A1 over A2A receptors in hypoxia; hypothesis-generating and should not yet change clinical practice.

Structured PICO

Population

Anaesthetized rats (n=23)

Intervention

Systemic hypoxia (breathing 8% O2 for 5 min) and adenosine (i.a. infusion for 5 min) before and after administration of selective adenosine A1 receptor antagonist DPCPX or selective adenosine A2A receptor antagonist ZM 241385

Comparator

Baseline responses before antagonist administration

Outcome

Changes in femoral vascular conductance (FVC), arterial blood pressure (ABP), and heart rate (HR)surrogate

Endogenous adenosine released during systemic hypoxia induces skeletal muscle vasodilatation primarily by acting on A1 receptors, whereas both A1 and A2A receptors mediate dilatation from exogenous adenosine.

Cite This Study

Bryan et al. (1999) studied this question.

synapsesocial.com/papers/6a8544869df997f4bbd6a464 https://doi.org/10.1111/j.1469-7793.1999.151af.x

View Full Paper

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Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider