February 10, 2009The Journal of PhysiologyOpen Access

Elucidation in the rat of the role of adenosine and A2A‐receptors in the hyperaemia of twitch and tetanic contractions

View Full Paper

Ask AI

Bookmark

Population

Anaesthetized rats divided into four groups

Comparison

ZM241385 followed by 8-sulphophenyltheophylline… vs Time controls receiving no antagonists

Design

Preclinical

Authors

CRClare J. RayUniversity of Manchester JMJanice M. MarshallUniversity of Birmingham

Discussion

Member takes

Implication

Rat data offer no clinical guidance on exercise hyperaemia; leaves open adenosine A2A contribution in human skeletal muscle.

Structured PICO

Population

Anaesthetized rats divided into four groups

Intervention

ZM241385 (selective A2A-receptor antagonist) followed by 8-sulphophenyltheophylline (8-SPT; non-selective adenosine receptor antagonist) before contractions

Comparator

Time controls (Groups 1 and 3) receiving no antagonists

Outcome

Femoral vascular conductance (FVC, FBF/ABP) and tension in the extensor digitorum longus muscle during isometric twitch and tetanic contractionssurrogate

Adenosine acting via A2A-receptors plays a greater role in the hyperaemia associated with tetanic contraction compared to twitch contraction in rats.

Cite This Study

Ray et al. (2009) studied this question.

synapsesocial.com/papers/6a890ef4d5f4e697bb131d9a https://doi.org/10.1113/jphysiol.2008.163683

View Full Paper

Ask AI

Bookmark

Elucidation in the rat of the role of adenosine and A2A‐receptors in the hyperaemia of twitch and tetanic contractions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Elucidation in the rat of the role of adenosine and A2A‐receptors in the hyperaemia of twitch and tetanic contractions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider