Key result
Precapillary PO2 below ~60 Torr increases lobar arterial pressure via upstream vascular sensors.
Why the study?
The mechanisms and sensor sites mediating pulmonary vasoconstrictor responses to graded decreases in precapillary blood PO2 and ventilatory hypoxia in intact-chest cats were not fully understood.
Does a reduction in precapillary blood PO2 increase pulmonary arterial pressure in intact-chest cats?
Population
Intact-chest cats
Comparison
Graded decreases in precapillary blood PO2 and ventilatory hypoxia versus baseline systemic arterial PO2 levels
Design
Preclinical experimental study with controlled lobar blood flow
Authors
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Additive precapillary and ventilatory hypoxia elevate feline lobar pressure; leaves open mechanisms and relevance to human pulmonary hypertension.
Does a reduction in precapillary blood PO2 increase pulmonary arterial pressure in intact-chest cats?
The study demonstrates that mixed venous blood PO2 may exert an important regulatory role in controlling pulmonary arterial pressure and vascular resistance via sensors upstream to the alveolar-capillary region.
Hyman et al. (1981) studied this question. Graded decreases in precapillary blood PO2 and ventilatory hypoxia was evaluated on Lobar arterial pressure. A reduction in precapillary PO2 to below 60 Torr increased lobar arterial pressure in intact-chest cats, indicating upstream sensor sites elicit a pulmonary vasoconstrictor response.
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