Key result
In anesthetized cats, hypoxia, hypercapnia, noradrenaline, dopamine, histamine, 5-HT, and propranolol increased pulmonary vascular resistance, while isopropylnoradrenaline and phentolamine decreased it.
Population
Anæsthetized artificially-ventilated cats with one lung lobe perfused at a constant rate of flow with…
Design
Preclinical
Authors
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Requires human validation before clinical consideration; leaves open role in pulmonary vascular disease management.
This preclinical study demonstrates the complex interplay of various vasoactive drugs, hypoxia, and hypercapnia on pulmonary vascular resistance in a feline model.
Barer et al. (1969) studied this question. Vasoactive drugs, hypoxia, and hypercapnia was evaluated on Changes in pulmonary vascular resistance. In anesthetized cats, hypoxia, hypercapnia, noradrenaline, dopamine, histamine, 5-HT, and propranolol increased pulmonary vascular resistance, while isopropylnoradrenaline and phentolamine decreased it.
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