Key result
Factor V Leiden and prothrombin 20210A mutations were associated with a diffuse cerebral infarct following cardiac angiography in a 2-year-old girl with tetralogy of Fallot.
Highlights the importance of evaluating genetic risk factors for thrombosis in patients with congenital heart disease who develop thrombotic complications.
A 2-year-old girl with tetralogy of Fallot presented with diffuse cranial infarct after cardiac angiography. Heterozygosity for factor V Leiden and prothrombin 20210A mutations were detected. The authors suggest that if thrombosis develops in patients with congenital heart disease, genetic risk factors should be evaluated.
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Sipahi et al. (2008) studied this question. Factor V Leiden and prothrombin 20210A mutations were associated with a diffuse cerebral infarct following cardiac angiography in a 2-year-old girl with tetralogy of Fallot.
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