Key result
In patients with acute myocardial infarction without known diabetes, high adiponectin levels at discharge independently predicted total mortality (adjusted HR 1.79; 95% CI 1.07-3.00; p=0.027).
Why the study?
Do elevated levels of adiponectin and leptin at discharge predict long-term mortality and cardiovascular events in patients with acute myocardial infarction without known diabetes?
Cohort (n=180)
Do elevated levels of adiponectin and leptin at discharge predict long-term mortality and cardiovascular events in patients with acute myocardial infarction without known diabetes?
Hazard Ratio: 1.79 (95% CI 1.07–3)
p-value: p=0.027
Elevated adiponectin levels at discharge independently predict long-term total mortality in patients with acute myocardial infarction without known diabetes.
Adiponectin and leptin may refine post-MI risk stratification in non-diabetics; leaves open added value beyond standard markers.
OBJECTIVE: Adiponectin and leptin are associated with insulin resistance and cardiovascular disease. Information on the prognostic value after an acute myocardial infarction is still conflicting. METHODS: Patients (n = 180) without known diabetes and with admission glucose of <11 mmol/L admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/heart failure) until the end of 2011 (median: 11.6 years). Plasma adiponectin and leptin were related to outcome in Cox proportional-hazard regression analyses. RESULTS: Median age was 64 years and 69% were male. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event. Adiponectin at discharge predicted cardiovascular events (hazard ratio; 95% confidence interval; 1.45; 1.02-2.07, p = 0.038), total mortality (2.53; 1.64-3.91, p < 0.001) and cancer mortality (3.64; 1.51-8.74, p = 0.004). After adjustment for age, sex, body mass index, previous myocardial infarction and heart failure, adiponectin predicted total mortality (1.79; 1.07-3.00, p = 0.027) but not cardiovascular events. High levels of leptin were associated with cardiovascular events during the first 7 years, after which the association was attenuated. Leptin did not predict total mortality. CONCLUSION: In patients with acute myocardial infarction but without previously known diabetes, high levels of adiponectin at discharge predicted total mortality. The present results support the hypothesis that high rather than low levels of adiponectin predict mortality after acute myocardial infarction.
No takes yet. Share an insight, caveat, or question.
Ritsinger et al. (2016) conducted a cohort in Acute myocardial infarction (n=180). High levels of adiponectin at discharge vs. Low levels of adiponectin was evaluated on Total mortality (HR 1.79, 95% CI 1.07-3.00, p=0.027). In patients with acute myocardial infarction without known diabetes, high adiponectin levels at discharge independently predicted total mortality (adjusted HR 1.79; 95% CI 1.07-3.00; p=0.027).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: